Aminocatalytic Domino Reactions: a cascade of possibilities: asymmetric catalysis, cascade catalysis, molecular complexity, organocatalysis, stereochemistry.

Abstract

Finding cost-effective and highly stereoselective ways to reproduce the rich structural diversity and complexity of natural molecules has always represented a formidable synthetic challenge for chemists, especially in relation to the study of biologically active compounds. The emerging field of aminocatalytic cascade reactions has recently provided a new strategy to recreate the intricate structural scaffold and related complex stereochemistry of natural-like compounds with very high fidelity. In this review we document how this energy-saving and sustainable synthetic strategy is becoming a reliable and versatile tool for modern asymmetric synthesis.